Antagonists of the TMEM16A Calcium-activated Chloride Channel Modulate Airway Smooth Muscle Tone and Intracellular Calcium
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چکیده
منابع مشابه
Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium.
BACKGROUND Perioperative bronchospasm refractory to β agonists continues to challenge anesthesiologists and intensivists. The TMEM16A calcium-activated chloride channel modulates airway smooth muscle (ASM) contraction. The authors hypothesized that TMEM16A antagonists would relax ASM contraction by modulating membrane potential and calcium flux. METHODS Human ASM, guinea pig tracheal rings, o...
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Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are hallmark features of inflammatory airway diseases, including asthma. Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM. The epithelial expression is increased in asthmatics, particularly in secretory cells. Based on...
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The transmembrane protein TMEM16A forms a Ca(2+)-activated Cl(-) channel that is permeable to many anions, including SCN(-), I(-), Br(-), Cl(-), and HCO3 (-), and has been implicated in various physiological functions. Indeed, controlling anion permeation through the TMEM16A channel pore may be critical in regulating the pH of exocrine fluids such as the pancreatic juice. The anion permeability...
متن کاملDownregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension through promoting basilar smooth muscle cell proliferation
Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension through promoting basilar smooth muscle cell proliferation Wang et al. TMEM16A CaCC and cerebrovascular remodeling Mi Wang, MD, PhD; Hui Yang, MD, PhD; Ling-Yun Zheng, PhD; Zheng Zhang, MD, PhD; Yong-Bo Tang, MD, PhD; Guan-Lei Wang, MD, PhD; Yan-Hua Du, MD, PhD; Xiao-Fei Lv...
متن کاملDownregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation.
BACKGROUND The Ca(2+)-activated chloride channel (CaCC) plays an important role in a variety of physiological functions. In vascular smooth muscle cells, CaCC is involved in the regulation of agonist-stimulated contraction and myogenic tone. The physiological functions of CaCC in blood vessels are not fully revealed because of the lack of specific channel blockers and the uncertainty concerning...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2015
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000000769